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phenobarbital will minimize the extent or outcome of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.phenobarbital decreases amounts of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with strong CYP3A4 inducers; these